If you are a developer, or even just interested in how development works (like me), you should be listening to Build & Analyze by the 5by5 Network. It’s hosted by Marco Arment of Instapaper fame and Dan Benjamin. The show is four episodes in and they generally last less than an hour, so it shouldn’t be too much trouble to catch up if you want to.
Dan is a fantastic host who keeps the discussion going, and Marco’s insight is grand, as usual.
Also, if you aren’t using Instapaper, shame on you.